These major centers of early Christianity, founded by the apostles, were looked to by their respective regions as leaders in Church life, and eventually their bishops came to be regarded as the primates of their areas. The members of the Pentarchy all participated in some form in the first eight Ecumenical Councils, from 325 to 880. Their relationship with each other, despite various periods of rivalry and dispute, was generally in terms of fraternal equality and conciliarity.